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Left Ventricle Relative Wall Thickness Can Predict Left Ventricle Diastolic Dysfunction

Hany Alfayed, Rashid Alhamdan, Yousef Maalof, Osama Maadarani, Abdelaziz Ashkanani, Moataz Daher

Med Sci Hypotheses 2018; 5:13-19

DOI: 10.12659/MSH.911721

BACKGROUND: We investigated the possible association between relative wall thickness (RWT) and left ventricle diastolic function. RWT provides information regarding left ventricle (LV) geometry independent of other calculations, precluding the requirement for most corrections.
MATERIAL AND METHODS: We recruited 49 patients undergoing 2D echocardiographic study of the diastolic left ventricle function and to measure RWT. Measuring Trans mitral E and A velocities, E/A and TDI to estimate E/e’ to grade the left diastolic function. RWT was calculated using this formula [(IVS+LVPW)/LVDD]. We used the standard way of measuring IVS, LVPW and LVDD. All patients had normal left ventricular systolic function, were in sinus rhythm, and had no valvular lesions or pericardial disease. Statistically, we were looking for a high correlation between RWT and diastolic function as evaluated by measuring E/A and E/e’ ratio.
RESULTS: There was a significant and high correlation between RWT and diastolic function of the left ventricle. RWT of more than 0.42 cm predicted diastolic dysfunction with a positive predictive value of 97.37 and a negative predictive value of 54.55%. An RWT more than 0.6 cm predicted high filling pressure of the left ventricle, with a positive predictive value of 83.97% and a negative predictive value of 94.95%.
CONCLUSIONS: RWT ≥0.42 cm can predict diastolic LV dysfunction and RWT OF ≥0.6 cm indicates elevated LV filling pressure. E/e’ is more correlated more with changes in RWT than E/A dose.

Keywords: Cardiomyopathy, Hypertrophic, Echocardiography, Heart Failure, Diastolic

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