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Amphetamine Use in Stroke Recovery: Rehabilitative Training Combined with Brain Stimulation

Shahid Bashir, Kaleem Imdad, Isaac TĂșnez

(Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia)

Med Sci Hypotheses 2017; 4:29-33

DOI: 10.12659/MSH.903804


ABSTRACT: Stroke is a physiological disorder that occurs when a prolonged local interruption of cerebral blood flow leads to massive neuronal death and short- or long-term functional impairment. People who experience major stroke retain some of their neural functional abilities for weeks and months, as abundantly reported earlier, and this recovery can reach a plateau at 6 months or later after injury. The focal goal of any stroke therapy in humans is the rehabilitation of functional capabilities related to autonomy and quality of life. In recent times, blending of acute d-Amph administration with rehabilitative training (RT) has revealed enormous remedial effects in animal models of stroke in clinical studies. In the present study, we hypothesized that the synergistic therapeutic effects of d-Amph coupled with RT administered during the early or late sub-acute period, combined with magnetic field stimulation, would improve neuronal activation, anatomic plasticity, and skilled motor functions in a middle-age rodent model of stroke. The results of the present study will advance understanding of the potential mechanism of d-Amph coupled with RT and magnetic field stimulation and their converging therapeutic effects in stroke recovery.

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